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PRESS RELEASES
May 15, 2003
Living Test for Mad Cow Disease. Results Presented at Centennial Celebration of German-American Collaborations in Microbiology.
ANN ARBOR, MI-- (Source: Chronix Biomedical) May 15, 2003 -- Research results from a living test for mad cow disease, otherwise known as bovine spongiform encephalopathy (BSE), developed through a German-American collaboration between the laboratories of Prof. Bertram Brenig, Director of the Institute of Veterinary Medicine, Georg August University (Göttingen, Germany) and Dr. Howard Urnovitz, CEO of the American genomics firm Chronix Biomedical (San Jose, California), will be presented for the first time at a scientific meeting May 17 at the Centennial Celebration of the founding of the University of Michigan Department of Microbiology and Immunology (Ann Arbor, Michigan).
The Chronix BSE blood test is anticipated to be the first licensed test that can be performed on living animals. Chronix expects to apply for governmental approval for this test during this calendar year. Current BSE tests can only be performed post-mortem on cow brain material. The post-mortem tests look for an abnormal protein known as a prion that is associated with the disease. The BSE blood test is considered a surrogate marker test since it detects blood RNA, not prion proteins.
Results presented in Ann Arbor show that the BSE blood test was 100% sensitive on all 6 BSE cows confirmed with a licensed prion test. The BSE blood test was 100% specific on all 46 animals from known healthy herds. The intriguing part of the study was that 3.5% (two animals out of fifty-seven) of cohort animals showed a positive response in the surrogate marker living BSE test. Cohorts are defined as all animals born and/or raised in the same herd as a confirmed BSE case within approximately 12 months before and after the date of birth of the index case. Positive cohort cases may represent animals at risk for developing BSE. The current regulations require all cohort animals to be slaughtered.
Professor Brenig says, “The fact that the at risk cohort group showed a higher percentage of detection as compared to healthy herds indicates to me that the current public policy of culling cohorts is the correct decision. The removal of all at risk cows from herds should help us greatly in containing the BSE problem. These results confirm our findings with the first generation of the living test. The next generation living test is easier to perform and should cost the same as the post-mortem tests.”
The development of the BSE test is a new landmark in the long history of German-American scientific collaboration. One hundred years ago, Dr. Frederick G. Novy returned from a research collaboration in Germany to establish the University of Michigan Department of Microbiology and Immunology, the first in the U.S. Simultaneously, Dr. Novy introduced to his fellow American scientists a new concept developed in the laboratories of Europe: the germ theory of disease. This year’s Centennial Celebration honors those historic events with two days of lectures presenting insights into today’s revolution in microbiology. Dr. Urnovitz, a Department graduate, is among the invited speakers at the highly-anticipated Centennial Celebration, where he will publicly present for the first time the results from the living test for BSE.
For additional information regarding Chronix Biomedical contact:
John DiPietro, Chief Financial Officer at 408-441-2072
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