(Nur etwas Feiertagslektüre um mal zu sehen, welche Soliden Tumore für BLUE in Frage kommen)
Hier eine ganz interessante Analyse zum Thema MAGE-A4, NY-ESO-1 (und SAGE);
In total, 585 samples in 21 tumour types were evaluated between June 2009 and March 2018. The positive expression rates of these CT antigens were as follows: MAGE-A4, 34.6% (range, 30.7–38.7); NY-ESO-1, 21.0% (range, 17.2–25.1); and SAGE, 21.8% (range, 18.5–25.4). The MAGE-A4 antigen was expressed in 54.9% of oesophageal cancers, 37.5% of head and neck cancers, 35.0% of gastric cancers and 34.2% of ovarian cancers; the NY-ESO-1 antigen was expressed in 28.6% of lung cancers, 25.3% of oesophageal cancers and 22.6% of ovarian cancers; and the SAGE antigen was expressed in 35.3% of prostate cancers, 32.9% of oesophageal cancers and 26.3% of ovarian cancers. The most common tumour type in this study was oesophageal cancer. MAGE-A4, NY-ESO-1 and SAGE antigen expression were assessed in 214 oesophageal cancer samples, among which 24 (11.2%) were triple-positive, 58 (27.1%) were positive for any two, 59 (27.6%) were positive for any one, and 73 (34.1%) were triple negative.
Oesophageal cancer exhibited a relatively high rate of CT antigen mRNA expression positivity...."
(Oesophageal cancer = Speiseröhrenkrebs)
In der letzten Veröffentlichung von MDG zum Thema MAGE-A4/Bluebird hiess es;
"..MAGE-A4 is highly expressed in a variety of cancer indications with unmet clinical need,
non-small cell lung cancer (NSCLC),
head and neck,
triple-negative breast, and
thereby representing a suitable target antigen for TCR-T immunotherapy..."
Adaptimmune beackert via MAGE-A4 Synovial Sarcoma, Myxoid Liposarcoma, Head and Neck Cancer, Esophageal Cancer, Esophageaogastric Junction Cancer, Urinary Bladder Cancer,Melanoma, Head and Neck Cancer, Ovarian Cancer, Non-Small Cell Lung Cancer, Esophageal Cancer, Gastric Cancer, Synovial Sarcoma, Myxoid Round Cell Liposarcoma, Gastroesophageal Junction.
Speiseröhrenkrebs wird also nicht ohne Grund bereits von Adaptimmune beackert.
Was bleibt dann für BLUE als beste Ziele?
Außer triple negative breast bleibt eigentlich nichts übrig, wenn man die von MDG genannten und die von Adap in der Klinik getesteten quervergleicht.
Hoffentlich legt sich BLUE da bald mal fest und veröffentlicht bald mal Infos zur geplanten Studie...
Möglichst noch lange vor der Firmenaufspaltung Ende des Jahres..