zeigen schon sehr eindrücklich, wieviel Wissen, Engagement und Aufwand (==Anlegergeld) in die Entwicklung geflossen sind. Aber sie zeigen auch, wie modern und attraktiv die Technologie ist (siehe die Freeline Therapeutics Neugründung um Miterfinder Dr. Hörer oder die Technologie des Adaptimmune Partners Universal Cells).
Viel zu schade jedenfalls, um ungenutzt bei Medigene zu verrotten und in den Finanzberichten verschwiegen zu werden.
Mein Appell als Investor an Medigene: Wenn ihr schon die KnowHow-Träger herausgetrieben habt und lieber eigene Interessen verfolgt, dann gebt den Entwicklungspartnern, Erfindern oder deren neuen Arbeitgebern die Möglichkeit mehr daraus zu machen! Eine 2-stellige Gewinnbeteiligung ist sicher drin - oder fürchtet ihr die Konkurrenz?
Als Beispiel schaue man sich nur die Tabellen 5 bis 7 mit den möglichen Antigenen und Indikationen an:
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Treatment in the context of the present invention refers to both therapeutic treatment and prophylactic or preventative measures, wherein the object is to prevent or slow down (lessen) the targeted pathologic condition or disorder. Those in need of treatment include those already with the disorder as well as those prone to have the disorder or those in whom the disorder is to be prevented.
Examples for autoimmune disease that are especially suitable for this invention are listed in Table 5.
TABLE 5
Autoimmune diseases and suitable antibody targets/antigens
Disease§antibody target/antigen
Myasthenia gravis Acetylcholine receptors
Graves's disease Thyroid-stimulating hormone
receptor
Thyroiditis§Thyroid
Insulin-resistant diabetes Insulin receptor
Asthma§Beta-2 adrenergic receptors
Juvenile insulin-dependent diabetes Pancreatic islet cells
Pernicious anemia Gastric parietal cells
Addison's disease Adrenal cells
Idiopathic hypoparathyroidism Parathyroid cells
Spontaneous infertility Sperm
Premature ovarian failure Interstitial cells, corpus
luteum cells
Pemphigus§Intercellular substance of skin
Primary biliary cirrhosis Mitochondria
Autoimmune hemolytic anemia Erythrocytes
Idiopathic thrombocytopenic purpura Platelets
Idiopathic neutropenia Neutrophils
Vitiligo§Melanocytes
Osteosclerosis and Meniere's disease Type-II collagen
Chronic active hepatitis Nuclei of hepatocytes
Goodpasture's syndrome Basement membranes
Rheumatoid arthritis Gamma globulin, virus-related
antigens, IL-6, IL-17, TNF-α
Sjogren's syndrome Nuclei and centromeres
Systemic lupus erythematosus Nuclei, DNA, RNA, erythrocytes,
etc.
Scleroderma§Nuclei and centromeres
Polymyositis§Nuclei, RNA
Preferred autoimmune diseases are asthma, Juvenile insulin-dependent diabetes (diabetes type 1) and rheumatoid arthritis. Therefore, preferred antigens are the corresponding antigens of Beta-2 adrenergic receptors, Pancreatic islet cells, Gamma globulin E, virus-related antigens IL-6, IL-17, and TNF-α.
Examples for tumor diseases that are especially suitable for this invention are listed in Table 6.
TABLE 6
Tumor diseases and suitable antibody targets/antigens
Disease§antibody target/antigen
Melanoma§HMW MAA (=high molecular weight
melanoma associated antigen), BAGE,
GAGE, MAGE-3, Melan A, MART-1, NY
ESO, gp 100, tyrosinase
Colon cancer CA125, EGFR
Gliobastome multiforme CA125, IL13R
(GBM)
Breast cancer Her2/NEU
Ovarian cancer L1 cell adhesion molecule
various cancers (e.g. for VEGF
colon cancer, small lung
cell carcinoma)
B-cell lymphoma, e.g. Non- CD20
Hodgkin Lymphoma
Examples for allergic diseases are asthma, especially atopic asthma, and all types of allergies. The preferred target antigens for vaccination against allergic diseases are IgE, IL9, and IL13, especially IgE.
An example for a metabolic disease is a disorder in the cholesterol metabolism (e.g. atherosclerosis), a preferred target antigen is CETP.
Examples for inflammatory diseases that are especially suitable for this invention are listed in Table 7.
TABLE 7
(Chronic) Inflammatory diseases
Disease
COPD (chronic obstructive pulmonary disease)
OA (osteoarthritis)
Rheumatoid arthritis
Polymyalgia rheumatica
Gouty arthritis, Gout, Pseudogout
Atherosclerosis
Crohn's disease (inflammatory bowel disease)
Shoulder tendinitis, Bursitis
Colitis
Multiple Sclerosis
Systemic Lupus Erythematosus
Psoriasis
Juvenile diabetes
Type I diabetes mellitus (insulin-resistant diabetes)
Hypothyroidism
Chronic fatigue syndrome
Kawasaki's disease
Cardiavascular disease
Pericarditis
Lymph adenopathy
Raynaud's phenomenon
Sarcoidosis
Sjogren's syndrome
Spondyloarthropathies
Vasculitides
Scleroderma
Goodpasture's syndrome
Wegener's granulomatosis
temporal = Giant cell arteritis
Celiac disease
Addison's disease
Autoimmune hepatitis
Grave's disease
Graft-vs-host disease
Preferred target antigens are IL-6, IL-17, TNF-α and CD20.
Examples for diseases in ophthalmology are age-related macular degeneration (AMD) and diabetic retinopathy, a preferred target in these indications is VEGF.
Other preferred diseases are Alzheimer disease with the target antigen β-amyloid.
The parvovirus mutated structural protein comprising at least one B-cell epitope heterologous to the parvovirus can be especially useful for manufacture of a medicament for breaking immune tolerance.
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