Actinium initiates mid-stage clinical trial of Actimab-A in patients with AML over age 60; shares rise 5% premarket
Sep 27 2016, 08:37 ET | About: Actinium Pharmaceuticals, ... (ATNM) | By: Mamta Mayani, SA News Editor
Actinium Pharmaceuticals (ATNM) initiates a Phase 2 clinical trial of Actimab-A in patients newly diagnosed with Acute Myeloid Leukemia (AML) who are over the age of 60. Actimab-A, Actinium's most advanced alpha particle immunotherapy (APIT) program, consists of the CD33-targeting monoclonal antibody, HuM195, and the alpha-emitting radioisotope, Actinium-225.
Actinium-225 gives off high-energy alpha particles as it decays which kills cancer cells.
The open-label study will enroll 53 patients. The primary endpoint is the complete response rate defined as complete remission or complete remission with incomplete platelet recovery. The secondary endpoint is overall survival. Top-line data should be available in H2 2017.
Shares are up 5% premarket on modest volume.
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