Was man so im Netz liest zwischen den Zeilen liest sich knisternd, zB...
twitter.com/grdollasign/status/480531787383185408
twitter.com/grdollasign/status/480531787383185408
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http://www.mdlinx.com/pharmacy/news-article.cfm/...hepatic-impairment
Narasimhan NI, et al. – This study evaluated the effects of chronic hepatic impairment on the single–dose pharmacokinetics (PK) of the tyrosine kinase inhibitor ponatinib. As no major differences in ponatinib single–dose PK were observed in patients with hepatic impairment versus healthy subjects, a reduction of ponatinib starting dose in these patients is not necessary, but caution is recommended when administering ponatinib to these patients.
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