VistaGen Therapeutics to Present at 9th Annual LD Micro Main Event

SOUTH SAN FRANCISCO, Calif., Nov. 30, 2016

During his presentation, Mr. Singh will provide an update on the Company's corporate progress and anticipated milestones for AV-101, its new generation, orally available CNS prodrug candidate in Phase 2 development, initially for the adjunctive treatment of major depressive disorder (MDD) in patients with an inadequate response to standard FDA-approved antidepressants.

A live webcast of the presentation will be available by accessing the IR Calendar in the Investors section of VistaGen's website (www.vistagen.com). A replay of the webcast will be available for 90 days, starting approximately two hours after the presentation ends.

About AV-101
AV-101 (4-CI-KYN) is an orally available CNS prodrug candidate, currently in Phase 2 development, initially for the adjunctive treatment of MDD in patients with an inadequate response to standard FDA-approved antidepressants. AV-101 also has broad potential utility in other CNS disorders, including chronic neuropathic pain and epilepsy, as well as neurodegenerative diseases, such as Parkinson's disease and Huntington's disease.

AV-101's mechanism of action is fundamentally differentiated from all FDA-approved antidepressants, with potential to drive a paradigm shift towards a new generation of safer and faster-acting antidepressants. Unlike standard antidepressants which act on serotonin and related neurotransmitter pathways in the brain, AV-101 works through an entirely different mechanism, mobilizing glutamate pathways to enhance neuronal plasticity and improve the communication between neuronal cells. Dysfunction in these activities is increasingly recognized by scientists as an important contributor to depression and other serious CNS disorders.

AV-101 is currently being evaluated in a Phase 2a monotherapy study in MDD. This study is being fully funded by the U.S. National Institute of Mental Health (NIMH), part of the U.S. National Institutes of Health (NIH). The Principal Investigator of the study is Dr. Carlos Zarate Jr., Chief, Section on the Neurobiology and Treatment of Mood Disorders and Chief of Experimental Therapeutics and Pathophysiology Branch at the NIMH.

VistaGen is preparing to advance AV-101 into a 280-patient, U.S. multi-center, Phase 2b adjunctive treatment study in MDD in the first half of 2017, prior to the completion of the NIMH-sponsored AV-101 Phase 2a monotherapy study. The Principal Investigator of the Phase 2b adjunctive treatment study will be Dr. Maurizio Fava of Harvard University.