PneumRx® Coils Included in New Global Clinical Guidelines and Given Positive Recommendation to Treat Severe Emphysema Patients in France

LONDON, December 5, 2016

BTG plc (LSE: BTG), the global specialist healthcare company, today announces the inclusion of treatment with PneumRx^® Coils in guidelines for the management of chronic obstructive pulmonary disease (COPD) published by the Global Initiative for Chronic Obstructive Lung Disease (GOLD). At the same time, the French Ministry of Health has published its positive recommendations regarding PneumRx^® Coils on its website.

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The updated GOLD guidelines now include endobronchial coils as a minimally invasive, bronchoscopic approach to reducing hyperinflation in severe emphysema patients. This update includes coils as a therapy option for emphysema predominant patients with severe hyperinflation, regardless of disease distribution or presence of collateral ventilation.

The French Ministry of Health published its positive recommendations regarding PneumRx^® Coils on its website as meeting an unmet medical need and fulfilling a public health interest based on therapeutic improvement over optimal medical therapy. This assessment will be a critical component in determining national reimbursement for treatment of patients with severe emphysema in France.

Both the GOLD recommendations and determination by the French Ministry of Health are based on two multicenter randomized controlled trials that examined the use of PneumRx^® Coils compared to usual care in changes in quality of life, lung function and exercise capacity in patients with advanced homogeneous and heterogeneous emphysema.

Guenter R. Janhofer, BTG Chief Medical Officer, commented: "We're pleased that both GOLD and the French Ministry of Health have acknowledged the value of PneumRx^® Coils for emphysema patients. In both randomized, controlled, multi-center studies, patients treated with the PneumRx^® Coil experienced improvements in quality of life, lung function, and exercise capacity. Data and imaging analysis is ongoing to further consider best practices for patient selection.  This analysis will be shared in upcoming publications to provide additional treatment considerations to physicians."