Inventiva completes a capital increase of € 8.2 million subscribed by leading US and European biotech investors

Donnerstag, 19.09.2019 08:45 von GlobeNewswire - Aufrufe: 469


  • New financing will enable the Company to extend from Q2 2020 to the end of Q3 2020 its cash runway beyond the ongoing lanifibranor and odiparcil clinical study results
  • Capital raised at the closing price of 18 September 2019 without discount
  • Entry into Inventiva’s capital by New Enterprise Associate (NEA) and renewed trust of BVF Partners L.P. and Novo Holdings A/S

Daix (France), September 19th, 2019
– Inventiva (Euronext: IVA), a clinical-stage biopharmaceutical company developing oral small molecule therapies for the treatment of diseases in the areas of fibrosis, lysosomal storage disorders and oncology, today announced the successful completion of a capital increase of €8.2 million subscribed by New Enterprise Associate (NEA), a leading US biotech investor and by BVF Partners L.P. and Novo Holdings A/S, two key current Inventiva shareholders. The capital increase was executed at the closing price of September 18, 2019 without any discount. In addition, Sofinnova Partners, current Inventiva shareholder and board member, through Sofinnova Crossover I Fund, a leading European venture capital firm specialized in Life Sciences, expressed an interest to acquire, as part of a future capital increase which may occur by the end of October 2019, up to additional 313,936 shares on similar terms, depending on the market conditions and in accordance with the corporate authorizations .

Frederic Cren, Inventiva’s Chairman and CEO, commented
: “We are very pleased with the successful completion of this placement, which supports our positive momentum across our product portfolio and which will allow us to further progress with our clinical and preclinical programs. We are excited to welcome among our shareholders a new tier-one US biotech investor, New Enterprise Associate (NEA), who has a substantial track record and strong expertise in our industry. At the same time, we are delighted that  BVF Partners L.P. and Novo Holdings A/S have renewed their trust in Inventiva. We thank them for their continued support. With this strengthened investor base in both the US and Europe, we now look forward to the clinical results of our two most advanced compounds, lanifibranor and odiparcil, which are expected in the first half of 2020 and by the end of this year respectively.”

Reasons for the issuance and use of the proceeds

Gross proceeds from the transaction are €8.2 million and  will primarily be used for general corporate purposes including funding operations and the development of the Company’s products, especially lanifibranor and odiparcil. This capital increase (which does not include Sofinnova's possible participation in a future transaction) will improve the financial horizon for the Company and extend it from Q2 2020 to end of Q3 2020, beyond the publication of the results of the NATIVE Phase IIb clinical study evaluating lanifibranor for the treatment of non-alcoholic steatohepatitis (NASH).

Key upcoming milestones

  • Results of the iMProveS Phase IIa clinical study in Europe evaluating odiparcil for the treatment of mucopolysaccharidosis type VI (MPS VI) (by the end of 2019)
  • AbbVie clinical milestone payment for ABBV-157, the drug candidate resulting from its collaboration with Inventiva for the treatment of moderate to severe psoriasis (H1 2020)
  • Results of the NATIVE Phase IIb clinical study evaluating lanifibranor for the treatment of non-alcoholic steatohepatitis (NASH) (H1 2020)

Key characteristics of the share capital increase

Inventiva's Board of Directors using the delegation of powers granted by the 5th resolution of the shareholders' general meeting held on January 18, 2019 (capital increase without the exercise of preemptive subscription rights in favor of categories of persons with specific characteristics) and in accordance with articles L. 225-138 of the French Commercial code (code de commerce), has decided today to realise a capital increase of 8,278,398.01 euros, by the issuance of 4,159,999 new shares with a nominal value of €0.01 each (the "New Shares") for a subscription price of €1.99 each (including premium) (the "Capital Increase").

It is specified that Sofinnova Partner having expressed an interest to participate in a capital increase on similar terms to those of this Capital Increase, did not take part in the vote at the Board of Directors' meeting.

Leading U.S. and European institutional investors, NEA, BVF Partners L.P. and Novo Holdings A/S specialized in healthcare and biotechnology participated in the capital increase, further diversifying and strengthening the Company’s shareholding structure.

The New Shares were issued with no discount to the closing price of the Company’s shares on the regulated market of Euronext Paris as at 18 September 2019.

Following the settlement-delivery expected to occur on 20 September 2019, Inventiva's share capital will amount to €265,321.76 divided into 26,532,176 shares. The New Shares will be fungible with the existing shares of the Company and will be admitted to trading on the regulated market of Euronext Paris under ISIN FR0013233012.

Impact of the offering on the share capital

The issuance of the New Shares represent 16% of the share capital of the Company after the Capital Increase. On an illustrative basis, a shareholder holding 1% of the Company’s share capital before the transaction will now hold a stake of 0.84% after the transaction.

The following table specifies the evolution of the share capital of the Company after the Capital Increase:



Before the Capital Increase
(on a non-diluted basis)
After the Capital Increase
(on a non-diluted basis)
Shareholders Number of shares % of the share capital % of the voting rights Number of shares % of the share capital % of the voting rights
Frederic Cren(1) 5,890,000 26.3% 36.4% 5,890,000 22.2% 32.2%
Pierre Broqua(1) 3,882,500 17.4% 24.0% 3,882,500 14.6% 21.2%
Subtotal - Acting in concert 9,772,500 43.7% 60.4% 9,772,500 36.8% 53.4%
BVF Partners L.P.(2) 3,334,564 14.9% 10.3% 4,001,402 15.1% 10.9%
NEA - - - 3,102,811 11.7% 8.5%
Novo Holdings A/S 1,951,970 8.7% 6.0% 2,342,320 8.8% 6.4%
Sofinnova 1,569,858 7.0% 4.8% 1,569,858 5.9% 4.3%
Perceptive Advisors 470,588 2.1% 1.5% 470,588 1.8% 1.3%
ISLS Consulting 111,000 0.5% 0.3% 111,000 0.4% 0.3%
Employees 533,251 2.4% 2.6% 533,251 2.0% 2.3%
Treasury shares 98,560 0.4% - 98,560 0.4%  
Other shareholders 4,529,886 20.2% 14.0% 4,529,886 17.1% 12.4%
Total 22,372,177 100.0% 100% 26,532,176 100.0% 100.0%

(1) Shareholders acting in concert under the terms of the shareholders' agreement entered into in connection with the admission of the Company's shares to trading on the Euronext regulated market in Paris.  
(2) BVF Partners L.P has a call option on shares held by Mr Cren and Mr Broqua exercisable at any time until 16 February 2020 (see section 6.2.6 of the 2018 registration document dated 12 April 2019).

Information available to the public and risk factors

Pursuant to Article 211-3 of the French financial market authority (Autorité des Marchés Financiers, “AMF”) General Regulation, it should be noted that the above-mentioned private placement has not resulted or will not result in the drafting of a prospectus submitted to the AMF for approval. Detailed information regarding the Company, including its business, financial information, results, perspectives and related risk factors are contained in the Company’s 2018 Registration Document (document de référence) filed with the AMF on April 12, 2019 under number R. 19-006. This document as well as other regulated information and all of the Company's press releases, can be accessed on the Company's website ( and/or AMF ( Your attention is drawn to the risk factors related to the Company and its activities presented in chapter 2 of its 2018 Registration Document.

The Company recalls that, since the publication of the 2018 registration document, significant information, in particular relating to the progress of its clinical programs and key figures as of June 30, 2019, has already been the subject of, prior to the publication of the half-yearly results and the half-yearly Financial Report scheduled for September 25, 2019, press releases available on the Company's website under the "News" and "Investors" sections.

This press release is not a prospectus within the meaning of the Prospectus Regulation (as defined below) nor a public offering.

About Inventiva

Inventiva is a clinical-stage biopharmaceutical company focused on the development of oral small molecule therapies for the treatment of diseases with significant unmet medical needs in the areas of fibrosis, lysosomal storage disorders and oncology.

Leveraging its expertise and experience in the domain of compounds targeting nuclear receptors, transcription factors and epigenetic modulation, Inventiva is currently advancing two clinical candidates – lanifibranor and odiparcil – in non-alcoholic steatohepatitis (“NASH”) and mucopolysaccharidosis (“MPS”), respectively, as well as a deep pipeline of earlier stage programs.

Lanifibranor, its lead product candidate, is being developed for the treatment of patients with NASH, a common and progressive chronic liver disease. Inventiva is currently evaluating lanifibranor in a Phase IIb clinical trial for the treatment of this disease for which there are currently no approved therapies.

Inventiva is also developing odiparcil, a second clinical‑stage asset, for the treatment of patients with MPS, a group of rare genetic disorders. The Company is currently investigating odiparcil in a Phase IIa clinical trial for the treatment of patients with the MPS VI subtype.

In parallel, Inventiva is in the process of selecting an oncology development candidate for its Hippo signalling pathway program. The Company has established two strategic partnerships with AbbVie and Boehringer Ingelheim in the areas of autoimmune diseases and idiopathic pulmonary fibrosis (“IPF”) respectively. AbbVie has started the clinical development phase of ABBV‑157, a drug candidate for the treatment of moderate to severe psoriasis resulting from its collaboration with Inventiva. Both collaborations entitle Inventiva to receive milestone payments upon the achievement of pre-clinical, clinical, regulatory and commercial milestones, in addition to royalties on any approved products resulting from the partnerships.

The Company has a scientific team of approximately 70 people with deep expertise in the fields of biology, medicinal and computational chemistry, pharmacokinetics and pharmacology a well as in clinical development. It also owns an extensive library of approximately 240,000 pharmacologically relevant molecules, around 60% of which are proprietary, as well as a wholly‑owned research and development facility.

Inventiva is a public company listed on compartment C of the regulated market of Euronext Paris (Euronext: IVA – ISIN: FR0013233012).  



Frédéric Cren
Chairman & CEO
+33 3 80 44 75 00

Brunswick Group
Yannick Tetzlaff / Tristan Roquet Montegon
Media relations
+33 1 53 96 83 83

LifeSci Advisors
Monique Kosse
Investor relations 212 915 3820


This announcement and the information contained herein do not constitute either an offer to sell or purchase, or the solicitation of an offer to sell or purchase, securities of Inventiva (the “Company”).

No communication or information in respect of the offering by the Company of its shares may be distributed to the public in any jurisdiction where registration or approval is required. No steps have been taken or will be taken in any jurisdiction where such steps would be required. The offering or subscription of shares may be subject to specific legal or regulatory restrictions in certain jurisdictions. The Company takes no responsibility for any violation of any such restrictions by any person.

This announcement does not, and shall not, in any circumstances, constitute a public offering nor an invitation to the public in connection with any offer. The distribution of this document may be restricted by law in certain jurisdictions. Persons into whose possession this document comes are required to inform themselves about and to observe any such restrictions.

This announcement is an advertisement and not a prospectus within the meaning of the Prospectus Regulation (as defined below), as implemented in each member State of the European Economic Area.

With respect to the Member States of the European Economic Area (including France) (“Member States”), no action has been or will be undertaken to make an offer to the public of the securities referred to herein requiring a publication of a prospectus in any Member State. As a result, the securities of the Company may not and will not be offered in any Member State except in accordance with the exemptions set forth in Article 1(4) of the Prospectus Regulation, or under any other circumstances which do not require the publication by the Company of a prospectus pursuant to Article 1 of the Prospectus Regulation and/or to applicable regulations of that relevant Member State.

For the purposes of the provision above, the expression “offer to the public” in relation to any shares of the Company in any Member State means the communication in any form and by any means of sufficient information on the terms of the offer and any securities to be offered so as to enable an investor to decide to purchase any securities, as the same may be varied in that Member State. The expression “Prospectus Regulation” means Regulation (EU) 2017/1129, and includes any relevant implementing measure in the Member State.

This document does not constitute an offer to the public in France and the securities referred to in this document can only be offered or sold in France pursuant to Article L. 411-2-II of the French Code monétaire et financier to (i) providers of third party portfolio management investment services, (ii) qualified investors (investisseurs qualifiés) acting for their own account and/or (iii) a limited group of investors (cercle restreint d’investisseurs) acting for their own account, all as defined in and in accordance with Articles L. 411-1, L. 411-2 and D. 411-1 to D. 411-4 and D. 754-1 and D. 764-1 of the French Code monétaire et financier. In addition, in accordance with the autorization granted by the general meeting of the Company’s shareholders dated January 18, 2019, only the persons pertaining to the categories specified in the 5th resolution of such general meeting may subscribe to the offering.

This document may not be distributed, directly or indirectly, in or into the United States. This document does not constitute an offer of securities for sale nor the solicitation of an offer to purchase securities in the United States or any other jurisdiction where such offer may be restricted. Securities may not be offered or sold in the United States absent registration under the U.S. Securities Act of 1933, as amended (the “Securities Act”) except pursuant to an exemption from, or in a transaction not subject to, the registration requirements thereof. The securities of the Company have not been and will not be registered under the Securities Act, and the Company does not intend to make a public offering of its securities in the United States. Copies of this document are not being, and should not be, distributed in or sent into the United States.

The distribution of this document (which term shall include any form of communication) is restricted pursuant to Section 21 (Restrictions on financial promotion) of Financial Services and Markets Act 2000 (“FMSA”). This document is only being distributed to and directed at persons who (i) are outside the United Kingdom, (ii) have professional experience in matters relating to investments and who fall within the definition of investment professionals in Article 19(5) of the Financial Services and Markets Act 2000 (Financial Promotion) Order 2005 (as amended) (the “Financial Promotion Order”), (iii) are persons falling within Article 49(2)(a) to (d) (high net worth companies, unincorporated associations, etc.) of the Financial Promotion Order or (iv) are persons to whom this communication may otherwise lawfully be communicated (all such persons referred to in (i), (ii), (iii) and (iv) above together being referred to as “Relevant Persons”). This document must not be acted on or relied on in the United Kingdom by persons who are not Relevant Persons. Any investment or investment activity to which this document relates is available only to Relevant Persons, and will be engaged in only with such persons in the United Kingdom.

This document may not be distributed, directly or indirectly, in or into the United States, Canada, Australia or Japan.


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