WORCESTER, Mass. and TORONTO, June 17, 2014
WORCESTER, Mass. and TORONTO, June 17, 2014 /PRNewswire/ -- Generex Biotechnology Corporation (www.generex.com) (OTCBB: GNBT) today announced the posting of an interview given by Dr. Eric von Hofe, Ph.D., President of the Company's wholly-owned subsidiary, Antigen Express, Inc. (www.antigenexpress.com), following his keynote presentation at the recent TIDES meeting. The 16th Annual TIDES Conference (www.IBCLifeSciences.com/Tides) was held in Providence, RI May 12 - 15, 2014. TIDES, Oligonucleotide and Peptide® Therapeutics from Research through Commercialization, is the premier meeting focused on the discovery and development of synthetic biologicals. The interview can be viewed online at:
During the interview, Dr. von Hofe pointed out the dramatic rise in the use of peptides as therapeutic agents over the last few years. Regarding their use as cancer vaccines, he noted that they represent the minimal unit required to generate an immune response. He further noted that dispensing with non-critical components unrelated to the specific immune stimulation one is seeking to elicit reduces the chances of non-specific side effects and toxicity. In addition, he explained how Antigen Express' specific peptide approach complements other non-specific immunotherapy strategies: while these non-specific approaches essentially take the brakes off the immune system, allowing it to attack 'self' tissues like cancer that it otherwise might not, the Antigen Express approach effectively 'steps on the gas' to stimulate the immune system in a very specific manner to attack tumor cells.
Antigen Express is in late Phase II trials of a second-generation peptide vaccine (AE37) designed to prevent relapse in patients with breast and other cancers. The AE37 peptide was designed using a fragment of the cancer-related HER2 protein combined with a proprietary modification to ensure activation of cells critical to the generation of a new immune response (CD4+ T helper cells). Recent results from a primary efficacy analysis indicate a trend toward reduced relapse in patients whose tumors express low to intermediate levels of HER2 who are not eligible to receive Herceptin. The protective effect of AE37 is even more pronounced in patients who have had triple negative breast cancer.
About Generex Biotechnology Corporation
Generex is engaged in the research, development, and commercialization of drug delivery systems and technologies. Generex has developed a proprietary platform technology for the delivery of drugs into the human body through the oral cavity (with no deposit in the lungs). The Company's proprietary liquid formulations allow drugs typically administered by injection to be absorbed into the body by the lining of the inner mouth using the Company's proprietary RapidMist™ device. Antigen Express, Inc. is a wholly owned subsidiary of Generex. The core platform technologies of Antigen Express comprise immunotherapeutic vaccines for the treatment of malignant, infectious, allergic, and autoimmune diseases. Antigen Express has pioneered the use of specific CD4+ T-helper stimulation technologies in immunotherapy. One focuses on modification of peptides with Ii-Key to increase potency, while a second relies on inhibition of expression of the Ii protein. Antigen Express scientists, and others, have shown clearly that suppression of expression of the Ii protein in cancer cells allows for potent stimulation of T-helper cells and prevents the further growth of cancer cells. For more information, visit the Generex website at www.generex.com or the Antigen Express website at www.antigenexpress.com.
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SOURCE Generex Biotechnology Corporation