Rock Creek Pharmaceuticals Announces Interim Amendments to Convertible Notes and Update on Financing Options

As disclosed in the Company's press release dated May 5, 2016, the Company is currently exploring a variety of additional financing options as a supplement or replacement for the convertible notes. Specifically, the Company has engaged an international life science focused investment advisory organization, on a best efforts basis, to assist in providing additional potential financing options from sources in the US and Europe. These financing options could involve the issuance of common or preferred equity, convertible or non-convertible debt instruments, license fees, or a combination of the foregoing.

Michael Mullan (MBBS, PhD), Chairman and Chief Executive Officer of Rock Creek Pharmaceuticals, commented, "Small drug development companies face a plethora of scientific, regulatory and financial challenges. We believe we have successfully navigated a variety of these challenges to date and have accomplished key milestones in our transition to a pharmaceutical development company. As a reminder, we have generated multiple pre-clinical demonstrations of the anti-inflammatory activity of our lead compound. We have successfully completed a Phase I human safety trial and we have aggregated resources (including three of the top dermatological experts in the world) to focus on dermatological indications, with a planned Phase Ib proof of concept study upcoming amongst other planned initiatives.  Management remains unwavering in its dedication and commitment to bringing the Company's technology to commercialization, as a novel way to treat damaging inflammatory conditions which burden young and old alike. In order to achieve this goal we continue to work on a number of alternative or additional financing strategies to adequately fund our preclinical and clinical programs necessary for regulatory approval."

About Rock Creek Pharmaceuticals, Inc.:

Rock Creek Pharmaceuticals, Inc. is an emerging drug development company focused on the discovery, development and commercialization of new drugs, formulations and compounds that provide therapies for chronic and acute inflammatory diseases. The Company is focusing on small molecule therapeutics that exhibit   anti-inflammatory pharmacological characteristics, distinct from other anti-inflammatory drugs available such as biologics, steroids and non-steroidal anti-inflammatories. The Company's lead compound has been investigated extensively in pre-clinical (in vitro and in vivo) studies, resulting in several peer reviewed and published scientific journal articles, covering models of multiple sclerosis, Alzheimer's disease, and autoimmune thyroiditis. All these studies demonstrated the anti-inflammatory effects of the Company's compound. In addition, the Company's compilation of human exposure safety and tolerability data has provided important insights for ongoing clinical and regulatory pharmaceutical development.

For more information, visit: http://www.rockcreekpharmaceuticals.com

Forward Looking Statements:
Certain statements contained in this release constitute forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. Such statements include, but are not limited to statements identified by words such as "believes," "expects," "anticipates," "estimates," "intends," "plans," "targets," "projects" and similar expressions. The statements in this release are based upon the current beliefs and expectations of our company's management and are subject to significant risks and uncertainties. Actual results may differ from those set forth in the forward-looking statements. Numerous factors could cause or contribute to such differences, including, but not limited to, failure to obtain sufficient capital resources to fund our development program and operations, results of clinical trials and/or other studies, the challenges inherent in new product development initiatives, including the continued development and approval of anti-inflammatory drug candidates, the effect of any competitive products, our ability to license and protect our intellectual property, our significant payables, our ability to raise additional capital in the future that is necessary to maintain our business, changes in government policy and/or regulation, potential litigation by or against us, any governmental review of our products or practices, pending litigation matters, as well as other risks discussed from time to time in our filings with the Securities and Exchange Commission, including, without limitation, our annual report on Form 10-K for the fiscal year ended December 31, 2015 filed on March 22, 2016. We undertake no duty to update any forward-looking statement or any information contained in this press release or in other public disclosures at any time.

CONTACT:

Investor Contact:
PCG Advisory Group
Stephanie Prince
646.762.4518
sprince@pcgadvisory.com

Media Contact:
PCG Advisory Group
Sean Leous
646 863 8998
sleous@pcgadvisory.com

Company Contact:
Rock Creek Pharmaceuticals, Inc.
2040 Whitfield Ave. Suite 300
Sarasota Florida, 34243
1-844-727-0727
IR@rockcreekpharma.com