Protagonist Therapeutics Appoints Sarah Noonberg, M.D., Ph.D. to the Board of Directors

NEWARK, Calif., Dec. 14, 2017

"Sarah Noonberg is a highly experienced drug development professional with a proven track record in leading clinical development programs for therapeutics in multiple areas of medicine, including orphan drugs for rare diseases. Her expertise spans from initial drug discovery to global regulatory approvals and commercialization," said Dinesh V. Patel, Ph.D., Protagonist President and Chief Executive Officer. "We believe Protagonist will benefit greatly from her broad experience as we continue to advance our three clinical assets towards the marketplace and move new drug candidates from our peptide discovery platform into clinical development.

"We are extremely thankful to Julie Papanek Grant for her valuable support and guidance to our company over the past several years as a member of the Protagonist Board," he concluded. "Julie played an instrumental role in assisting Protagonist with our private fundraising efforts before our initial public offering in 2016."

Dr. Noonberg has served as Prothena's Chief Medical Officer since May 2017. Prior to joining Prothena, she served as Group Vice President and Head of Global Clinical Development at BioMarin Pharmaceuticals Inc., where she was responsible for development strategy and execution across a diverse clinical portfolio. From 2007 to 2015, Dr. Noonberg held several positions at Medivation, Inc. where, as Senior Vice President of Early Development and Vice President of Clinical Development, she led programs across all phases of development, including enzalutamide for the treatment chemotherapy-naïve metastatic prostate cancer. She also held several clinical positions between 2004 and 2007 at Chiron Corporation, where she led the clinical development of compounds in infectious disease and pulmonary indications. Dr. Noonberg earned her M.D. at the University of California, San Francisco and her Ph.D. in Bioengineering at the University of California, Berkeley. Dr. Noonberg is a board-certified internist and completed her residency at Johns Hopkins Hospital. Since 2002, she has been an active part-time hospitalist, working as an attending physician treating a broad range of inpatient and critical care patients.

About Protagonist Therapeutics

Protagonist Therapeutics is a clinical-stage biopharmaceutical company with a proprietary technology platform which is utilized to discover and develop novel peptide-based drugs to address significant unmet medical needs. Its primary focus is on developing potential first-in-class, oral targeted therapy-based peptide drugs that work by blocking biological pathways that are currently targeted by marketed injectable antibody drugs. Protagonist's initial lead peptide product candidates, PTG-100 and PTG-200, are based on this approach, and the company believes these candidates have the potential to transform the existing treatment paradigm for inflammatory bowel disease (IBD), consisting primarily of ulcerative colitis and Crohn's disease.