Ampio Pharmaceuticals Provides Corporate Update

ENGLEWOOD, Colo., March 20, 2017

As previously stated in the February 27, 2017, press release, FDA acknowledged an unmet medical need in patients with pain due to severe OAK, graded as Kellgren-Lawrence Grade 4 (KL 4), where there are currently no FDA-approved treatments for this population.

Also, Ampio is pleased to announce that after an extensive process, the board of directors has selected Locust Walk to serve as a strategic advisor to the company.  Locust Walk's charter will be to identify and evaluate potential strategic relationships for Ampion™.  Among the many reasons, Locust Walk was selected due to their recent experience in securing transactions for similar stage therapeutics to treat pain as well as extensive knowledge of the OAK market. "I am very excited about Ampio's current position," said Michael Macaluso, Chairman, and CEO.  "In the history of the company, we have never been as close to realizing what we believe to be the full potential of Ampion™, both from a regulatory perspective as well as commercial.  I am thrilled to be working with Locust Walk to identify the optimal path to unlocking the value of Ampion™ for both patients and shareholders."

About Osteoarthritis:
Osteoarthritis is a progressive disorder of the joints involving degradation of the intra-articular cartilage, joint lining, ligaments, and bone. The incidence of developing osteoarthritis of the knee over a lifetime is approximately 45%. As this disease is associated with age, obesity, and diabetes, this number will continue to grow. Certain risk factors in conjunction with natural wear and tear lead to the breakdown of cartilage. Osteoarthritis is caused by inflammation of the soft tissue and bony structures of the joint, which worsens over time and leads to progressive thinning of articular cartilage. Other symptoms include narrowing of the joint space, synovial membrane thickening, osteophyte formation and increased density of subchondral bone.

About Ampio Pharmaceuticals:
Ampio Pharmaceuticals, Inc. is a development stage biopharmaceutical company primarily focused on the development of therapies to treat prevalent inflammatory conditions for which there are limited treatment options. We are developing compounds that decrease inflammation by (i) inhibiting specific pro-inflammatory compounds by affecting specific pathways at the protein expression and at the transcription level; (ii) activating specific phosphatase or depletion of the available phosphate needed for the inflammation process, and (iii) decreasing vascular permeability.

About Locust Walk:
Locust Walk is a leading life sciences transaction advisory firm focused on biopharmaceutical and medical technology companies.  Our team of experienced professionals fuels the growth of promising companies at every stage by connecting the right products, the right partners and the most attractive sources of capital – driving innovation for growth and transformative results.
Locust Walk was founded in 2009 and currently has offices in Boston, San Francisco, Tokyo Japan and Cologne Germany. Over the past two years, Locust Walk has completed 19 transactions for its clients around the world. For further information, please visit www.locustwalk.com