Wichtige, eilige Frage

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Wichtige, eilige Frage THESHARE
THESHARE:

Wichtige, eilige Frage

 
03.05.00 15:20
#1
Hat jemand eine Meinung zu Viropharma, ich überlege sie heute noch zu kaufen.

Danke im voraus.

Wichtige, eilige Frage Kalahari
Kalahari:

Re: Wichtige, eilige Frage

 
03.05.00 15:30
#2
Mahlzeit,
habe diesen Artikel hier gefunden. Ist allerdings schon vom 11.04.
Vielleicht hilft Dir das bei Deiner Entscheidung. In letzter Zeit sind
einige Biotech-Titel kräftig zurückgekommen. Als Alternative kannst Du Dir ja mal Millenium oder Celgene anschauen.

Viel Glück,
kalahari



ViroPharma Plunges as Its Top Product Fails Test
By Michael Brick
TheStreet.com/NYTimes.com Staff Reporter
4/11/00 4:39 PM ET  



Updated from 12:19 p.m. EDT

No one expected ViroPharma (VPHM:Nasdaq - news - boards) to put a man on the moon. No one ever said the Exton, Pa., company might save the whales. In fact, investors who have more than doubled the company's stock price in the past three months were counting on one thing alone: A cure for the common cold, delivered next year.

On Tuesday, many of those investors lost their patience.



The much-ballyhooed drug Pleconaril, which the company had said it might sell by the end of the year to treat viral meningitis and by next year to treat colds, fell short in two major clinical tests, the company disclosed.

Shares of ViroPharma fell 48 1/2, or 67%, to 23 1/4 at Tuesday's closing. They had reached an all-time high of 111 5/8 last month. Since last spring, the five-year-old company's shares have grown from a 52-week low of 6 1/8.

The stock plunge began after the company said that in Phase III studies, the drug failed to significantly reduce the time of illness in adults treated for viral respiratory infection, an extreme strain of the disease known as the common cold.

"We are confident in Pleconaril's ability to help these patients," said Claude Nash, the company's chief executive, in a statement. He said the company plans to maintain its schedule to file for regulatory approval to market the drug as a treatment for viral respiratory infection.

Pleconaril also did not substantially best placebos in treating children with viral meningitis, the company said. The schedule for filing for regulatory approval to treat viral meningitis may be revised, Nash said.

The drug, developed by scientists who experimented with 1,500 versions before beginning human testing, is intended to block 169 different viruses. It inhibits the function of the picornavirus capsid, a protective protein shell that surrounds viruses, enabling them to infect humans and to be transmitted between them. The drug attacks a site on the capsid common to rhinoviruses and enteroviruses.

Both are versions of a larger class, the picornavirus. The Food and Drug Administration sets strict guidelines for testing any product claiming to cure or relieve enterovirus infections, including colds, because they are known to spontaneously vanish on their own.

As ViroPharma has labored to create the drug, the company's shares have ridden a wave of stock market enthusiasm for biotechnology companies.

According to ViroPharma's most recent filings with the Securities and Exchange Commission, the company has never made any revenues, depending on cash raised in the debt and equity markets to finance its research operations.

That research, devoted primarily to developing Pleconaril, has caused a cumulative net loss of $67.1 million through Sept. 30, 1999.

Since a wave of publicity in January, when the firm Strategic Research Institute began promoting the drug as the centerpiece of a March medical conference, investors have poured money into the company's stock, buying into a business plan that depended on little other than Pleconaril.

The company's stock traded for less than $40 a share until the middle of January.

In a Jan. 25 news release, Strategic Research said the drug "excited the scientific community by demonstrating efficacy in the common cold as well as neonatal sepsis, myocardis, enterovirus infected inpatients with severe combined immunodeficiency and vaccine-acquired polio."

Doctors who have tested the drug on patients added to the excitement. "This is the cure for the common cold," Dr. Jose Romero, of Creighton University in Omaha, Neb., told the Los Angeles Times in an article published on Jan. 24.

Analysts said the results released Tuesday were not catastrophic, adding that the drug could easily be approved to treat many of the ills the company said it might.

After a conference call with company officials on Tuesday, Wall Street analysts said ViroPharma would have to rethink its plans to market the drug as a treatment for viral meningitis. Mark Augustine, an analyst for U.S. Bancorp Piper Jaffrey, said the company would have to decide "where they go from here in viral meningitis."

But experiments have shown the drug successful in treating influenza, and the drug can still be approved for a variety of uses, Augustine said. "Pleconaril has shown demonstrable biological effects and the company must now demonstrate clinical effects," he added.

"They're going to have to carefully craft the next set of clinical studies," said Augustine. The analyst lowered his rating from strong buy to buy based on the news. His firm co-managed a secondary stock offering for ViroPharma in October 1999 and co-managed a debt offering in February.

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Wichtige, eilige Frage THESHARE
THESHARE:

Re: Wichtige, eilige Frage

 
03.05.00 16:41
#3
Danke für die Antwort, ich werde jetzt aber wohl doch eher Medarex kaufen, trotzdem vielen Dank!
Wichtige, eilige Frage Kalahari
Kalahari:

Zu Medarex

 
04.05.00 08:32
#4
Ein paar Medarex hab ich mir Anfang letzter Woche auch zugelegt. Mal sehen, was daraus wird.

Gruß,
kalahari
Wichtige, eilige Frage papadope

guter Start

 
#5
Guter Start +7% etc... 8) go .....


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